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In GSH_d, the entire conformation is pulled towards the L2 region, with the glycine part losing its hydrogen bond with R289 and forming an interaction with K315 (Fig

Since the data followed a normal distribution, one-way ANOVA was used to compare group means, with a significance level set at P 0.05 (n = 6 animals per group)

Furthermore, curcumin has been shown to activate ferroptosis in follicular thyroid cancer by increasing HO-1 expression, further supporting the therapeutic potential of ferroptosis in thyroid cancer (63)