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10.1016/j.jsbmb.2009.01.011 30 FangJ.ChenQ.HeB.CaiJ.YaoY.CaiY.et al (2018)

CypD knockout (KO) in elderly mice showed better anti-aging effects, such as inhibition of mitochondrial swelling and a higher NAD+/NADH ratio, but further exploration is needed to explain the exact mechanism in heart tissue [38]