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SOP: physical examination and laboratory testing for men with erectile dysfunction

However, the activity of HIF signaling in diabetic kidney is still controversy with one study reported tubule-specific knockout of HIF-1 aggravated kidney dysfunction and renal histopathological alterations in streptozotocin-induced diabetic mice (Jiang et al., 2020), and another elegant study, on the contrary, found that a specific inhibitor of HIF-1 attenuates the manifestations of diabetic nephropathy in OVE26 type 1 diabetic mice (Nayak et al., 2016)

10.1073/pnas.2637002100 Proc

However the exact mechanism of this effect is not understood