ipamorelin clinical trial growth hormone secretion safety human study randomized Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Applications, and Future Perspectives and Efficacy of Approved – Ipamorelin Selectivity in Growth Hormone

10.1038/s41598-018-25516-3 173 StevenS.FrenisK.OelzeM.KalinovicS.KunticM.Bayo JimenezM

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Although for some time there was talk of the NF1-Noonan syndrome to describe children with the Noonan phenotype and pigmentary cutaneous manifestations fully typical of NF1, subsequently, it was shown that these patients had mutations in the NF1 gene and they actually did not have Noonan syndrome but a true form of NF1.26 Specifically, missense mutations in the NF1 gene that affect the p.Arg1809 residue have typical phenotypes of Noonan syndrome (pulmonary stenosis and short stature) and typical pigmented lesions of NF1, but absence of neurofibromas.25 CaLS of patients with LEOPARD syndrome usually have a darker tone (past literature has described these as black coffee spots instead of CaLS), often with a heterogeneous color

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