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2 and 3 are shown in Supplementary Data 1

101 Despite major advances in the acknowledgment of tissue-specific NAD + homeostasis, further work will be needed to fully characterize the subcellular and systemic modulation of NAD + metabolism, which can improve the preventive and therapeutic strategies based on maintaining healthy NAD + homeostasis

The excellent ORR efficiency was ascribed to the powerful electron-coupling interactions between the active Co 3 O 4 sites and the Fe, N-co-doped carbon substrate, resulting in the loading of additional intensely active Co 3 O 4 sites on the substrate, which greatly improved the electronic conductivity and mass transport efficiency