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RAS is the most commonly-mutated oncogene in cancer its mutations mean its always on, forcing continuous proliferation and contributing to the extremely poor survival in this disease (3% at 5 years for metastatic disease)

As dopamine does not cross the digestive mucosa or the bloodbrain barrier, oral administration of its lipophilic precursor l-dopa remains pivotal as therapy 1

The clinical data at this dose is robust

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