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CRYAA expression levels have been reported to be reduced in ARC lenses, with hypermethylation of the CRYAA gene promoter CpG islands representing a key mechanism for CRYAA downregulation (230)

Its sequence is Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2, with molecular formula C78H111N21O19 and a molecular weight of 1646.8 g/mol