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Taken together, under normal conditions, APAP-induced cell death involves peroxynitrite-mediated mitochondrial dysfunction but LPO and ferroptosis are unlikely to play a relevant role in the pathophysiology

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However, these benefits come with a caution: recipients may develop nutritional deficiencies years after treatment that can carry their own health risks if not properly managed

The research ethics committee of the School of Medicine, Tohoku University, approved this study, which was conducted in accordance with the ethical guidelines of the 1975 Declaration of Helsinki