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Inhibition of Exo70, an Exocyst Complex Component, Enhances mRNA Delivery Efficiency of Lipid Nanoparticle Ha and Yong Main findings: Co-treatment of mRNA/LNP with Exo70 inhibitor enhances mRNA delivery efficiency in cell lines In vivo results demonstrate mRNA delivery in combination with Exo70 inhibitor highly improves mRNA delivery efficiency Implications: Exocytosis has been recognized as a obstacle for mRNA/LNP delivery This study demonstrates that the inhibition of Exo70, a component of exocyst complex, could be a novel strategy to improve mRNA delivery of LNP system To view or add a comment, sign in Clinical Fact Of The Day Did You Know Macular Degeneration Treatment May Soon Swap Monthly Eye Injections for Simple, Needle-Free Eye Drops

For example, asymptomatic stones discovered during diagnostic imaging may not be treated, but an acute symptomatic kidney stone demands an intervention, even if only hydration and painkillers for a small stone (Curhan 2012

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These are inexpensive and available from laboratory supply companies