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The brain substantia nigra in PD has a high level of expression of the VD metabolizing enzyme and 1 hydroxylase, and VD can stimulate the expression of tyrosine hydroxylase, a key enzyme of dopamine synthesis in PD, which affects the production and turnover of dopamine, therefore, the role of VD in the development process of PD has received increasing attention (85, 86)

It serves numerous essential functions, including: The liver helps protect against insults from foreign compounds as well as substances formed as metabolic byproducts

GPX4 aggravates experimental autoimmune encephalomyelitis by inhibiting the functions of CD4 T cells