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Meta-analysis (2015) : Four RCTs (n=523) showing ALC significantly reduced VAS pain scores in peripheral neuropathic pain (MD 1.20

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Thus, on top of the direct beneficial effects of ketone bodies including antioxidative and anti-inflammatory functions (discussed in [169,170]), IF (but also very-low-carbohydrate-diets) could reverse this so-called ketogenic insufficiency that has been observed in NAFLD [171] by increasing hydrolysis of IHLC partitioning fatty acids towards ketogenesis, thereby improving mitochondrial redox state [20]