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Furthermore, the trial failed to show any statistically significant difference in the time of removal of the immobilization device, which was the primary end point of the study [108]

For instance, some patients report increased energy as their neurological function improvesthis is a therapeutic effect rather than a true adverse reaction

Figure 1: Showed the right mandibular edentulous ridge of a patient diagnosed with CTN and the fabricated stent to cover the painful site Pharmacological methods Pharmacological treatments include antidepressants (e.g., SSRIs, SNRIs, TCAs) and anticonvulsants (e.g., gabapentin, carbamazepine), which suppress neuronal hyperexcitability