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214,215,216,217 Additionally, sensory neurons in the dorsal root ganglia (DRG) exhibit altered phenotypes, such as reduced neurofilament synthesis, endoplasmic reticulum stress, and changes in key plasticity molecules, such as growth-associated protein 43 (GAP43) and heat shock proteins, leading to mitochondrial dysfunction and loss of peripheral nerve function

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doi: 10.3389/fphar.2021.760581 Received 18 August 2021 Accepted 17 September 2021 Published 26 October 2021 Volume 12 - 2021 Edited by Xuefeng Li, Guangzhou Medical University, China Reviewed by Xiangling Meng, Stanford University, United States Yitian Xu, Houston Methodist Research Institute, United States Qiang Qin, University of Texas MD Anderson Cancer Center, United States Dandan Zhu, University of Texas Health Science Center at Houston, United States Updates Copyright 2021 Wang, Wang, Liao, Hu, Chen, Meng, Gao and Li