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the excess free radicals deplete glutathione reserves, and the decreased ATP production slows glutathione replenishment, ultimately resulting in chronic glutathione deficiency [8]

Rooibos has been consumed by locals for over 300 years, but it was not known outside South Africa until 1904 when Benjamin Ginsberg, a Russian immigrant to South Africa, recognized its potential and started trading with rooibos that he bought from the Khoi descendants and became the first exporter of rooibos

In addition, the proportion of patients with a 20% decrease in CHI3L1 was significantly higher in the regression group than in the non-regression group at 52 weeks of treatment (56.6% vs