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[39] These allergic reaction-like symptoms, which typically occur within 3060 minutes of ingesting alcoholic beverages, do not appear to reflect the operation of classical IgE- or T cell-related allergen-induced reactions but rather are due, at least in large part, to the action of acetaldehyde in stimulating tissues to release histamine, the probable evoker of these symptoms

There is no human trial defining an optimal cycle length for the blend