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60 YEARS OF POMC: Transcriptional and epigenetic regulation of POMC gene expression

Combined with GH secretagogue peptides that drive the anabolic signaling for protein incorporation, this combination addresses both the signal (peptides) and the substrate (amino acids) of muscle building simultaneously

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However, with the more recently introduced SGLT2 inhibitors and GLP-1 receptor agonists having shown impressive cardiovascular risk reduction in addition to glycemic control efficacy, these newer agents may also be considered as first-line therapies in patients with pre-existing cardiovascular or renal disease (Garber 2020)