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Properties of aromatic amino acids The aromatic amino acids (phenylalanine, tyrosine and tryptophan), whilst all falling within other classifications, possess aromatic side chains

CB1R, but not CB2R, exerts a protective role in colonic permeability as shown in CB1R knockout mice that respond to stress with enhanced permeability compared to normal littermates [53]

Its capacity to promote tumor cell proliferation, activate oncogenic signaling pathways such as STAT3, facilitate immune suppression, and stimulate angiogenesis underscores its active participation in tumor biology

A high-fiber diet can trigger this mechanism by enriching the population of Akkermansia muciniphila , which produces c-di-AMP and enhances the therapeutic effect of ICB in melanoma patients