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Some proponents suggest that metformin's effects on insulin signaling and cellular metabolism could theoretically influence melanin production, but this hypothesis lacks substantiation through rigorous clinical trials

Thirty participants were enrolled with native liver, and 6 (20%) had possible or definite clinically evident portal hypertension at the time of enrollment (n=3 with HSD3B7, n=2 with AKR1D1 deficiency, n=1 with a conjugation defect)