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Lin Z, Yu S, Yang Y, et al (2024) The double-edged effects of substance P in the pathology of Alzheimers disease

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In both the P4S-bound or apo inward-open structure, a pronounced bend of TM1a towards the membrane plane, coupled with unwinding of the intracellular side of TM5, collectively open a solvent-accessible pathway to the cytoplasm (Fig