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The first bottleneck is supply : damaged tissue needs fresh blood vessels to deliver oxygen, nutrients and repair signals

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Disclosures: Farzaneh Tamnanloo: Nothing to Disclose, Quang Toan Pham: Nothing to Disclose, Marie-Agns MCallum: Nothing to Disclose, Denis Cyr: Nothing to Disclose, Paula Waters: Nothing to Disclose, Emilie Beaulieu: Nothing to Disclose, Yannick Doyon: Nothing to Disclose, Ugur Halac: Nothing to Disclose, Claudia Raggi: Nothing to Disclose, Massimiliano Paganelli: Morphocell Technologies: Executive role 2500 THE RELATIONSHIP BETWEEN SERUM BILE ACIDS AND EVENT-FREE SURVIVAL FOLLOWING THE USE OF MARALIXIBAT FOR PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS: DATA FROM MARCH/MARCH-ON Richard Thompson 1 Lorenzo D'Antiga 2 Simon Horslen 3 Douglas Mogul 4 Tiago Nunes 4 Will Garner 4 Pamela Vig 4 Alexander Miethke 5 , 1 King's College London, United Kingdom, 2 Papa Giovanni XXIII, Bergamo, Italy, 3 UPMC Children's Hospital of Pittsburgh, Pennsylvania, 4 Mirum Pharmaceuticals, Inc., Foster City, California, 5 Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio Background: Maralixibat, an inhibitor of the ileal bile acid transporter, is approved in the US for treatment of cholestatic pruritus in individuals 3 months with Alagille Syndrome (ALGS) and 5 years with Progressive Familial Intrahepatic Cholestasis (PFIC)