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Moreover, Fan and colleagues found that Grx activity gradually declines with age, and its expression is significantly reduced in the anterior capsule membrane of patients with ARC, corresponding with elevated phosphorylation of extracellular-signal regulated kinase (ERK) [75]

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A pooled analysis of six randomized placebo-controlled trials (n=618) indicated that responses at 4 weeks may predict response at 6-9 weeks, although another pooled analysis of open-label data (n=338) suggests that the probability of a robust response to atomoxetine [40% decrease in ADHD-Rating Scale (ADHD-RS) scores] may continue to increase beyond 6-9 weeks