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MZB have the potential to self-renew 18 and are activated more quickly than FoB 7,8 , properties consistent with a requirement for glycolytic reprogramming in activated B cells 101

Additionally, various antivirals have been shown to induce inflammatory signals and it is therefore plausible that if an altered immune-organization is seen in HAART treated patients it is due to antiretroviral therapy (Mondal et al., 2004