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This AOP identifies the deposition of ionizing energy as the MIE, leading to DSB and subsequent mutations due to the errors in DNA repair mechanisms

A number of research confirmed a strong involvement of oxidative stress in the pathophysiology of neurodegenerative diseases through a variety of mechanisms including induction of oxidation of macromolecules such as nucleic acids, proteins, lipids, mitochondrial dysfunction, glial cell activation, amyloid deposition, apoptosis, and proteasome dysfunction [3, 5, 10, 11]

In many cases, it is not simply diet

"We continue to support our players during this process and we have brought in independent medical and pharmacological advice which has provided comfort to the Club about the safety of our players