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However, tumor cells often downregulate HLA-I and allow effector NK cells to be activated by immunoreceptor tyrosine-based activation motifs (ITAMs) in intracellular domains, resulting in the release of cytokines, perforins and granzyme B and leading to tumor cell death

Direct head-to-head randomized human trials are practically non-existent, so comparisons regarding human efficacy should be interpreted carefully

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doi: 10.1016/j.tem.2016.06.010 40 YoshidaTSemprun-PrietoLSukhanovSDelafontaineP