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This again represents a dramatic increase from estimates of 18 in 1000 children reported to have such conditions sufficiently severely to interfere with usual daily activities in the 1960 s [424] and estimates of 1 in 100 to 1 in 25 children under 16 to have a severe chronic illness in the 1980 s [202]

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In another study, significant improvements were observed in the ABC scale score of 36-week sulforaphane supplementation in children with ASD compared to the placebo group [121]

Conclusions To properly treat this rare syndrome, we propose classifying it as either dynamic or static, on the basis of the clinical history, MRI findings, and physical examination