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Furthermore, apoptotic cells in SLE often congregate in germinal centers to avoid macrophage clearance and deliver survival signals to autoreactive B cells, which may contribute to the loss of immune tolerance (86)

The high concentrations of pharmacological BH4 that are required to generate a biological effect in many studies suggest that biopterins do not enter cells merely by passive diffusion

Hoque MA, Chisty NN, Guttin T, Irin N, Baillie S (2023)

LozanoRNaghaviMForemanKLimSShibuyaKAboyansVet alGlobal and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010