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By mapping the cascade from zinc imbalance to molecular dysfunction, organelle stress and disease expression, the framework provides an early overview that anchors the detailed sections that follow and highlights mechanistic points of intervention with potential relevance for future therapeutic modulation 18,19,20,21

For decades, a variety of medications have been studied for the treatment or prevention of radiation-induced tissue fibrosis and most of them yielded promising results (Table 1)

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doi:10.1111/j.1742-7843.2006.pto_523.x Pritsos CA, Sokoloff M, Gustafson DL (1992) PZ-51 (Ebselen) in vivo protection against adriamycin-induced mouse cardiac and hepatic lipid peroxidation and toxicity