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The most prominent of these is spectrin, a filamentous protein that forms a supportive lattice beneath the membrane, critical for the biconcave disk shape and for providing the flexibility needed to traverse narrow capillaries (9)

The increase in glutathione abundance was due to a proportional rise in both the reduced (GSH) and oxidized (GSSG) forms of glutathione

The formation and progression of cysts in ADPKD are also associated with oxidative stress, inflammation, and cell death (268, 269)

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