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Reproductive toxicology reveals that prolonged 2550 mg/kg AP administration in male rats induces sperm count reduction, motility impairment, and teratozoospermia - though this observation suggests potential male contraceptive applications ( in vitro while increasing tumor burden in vivo ( In conclusion, while AP, SHK, ADA, and related compounds exhibit multi-faceted pharmacological potential, their toxicological profiles and adverse effect manifestations remain clinically significant

307,308 Additionally, GLP-1R signaling may affect other macrophage functions, such as phagocytosis, migration, and cell survival

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