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Description

We can change the conformation and function of mutant p53 via pharmacological intervention in specific posttranslational modification pathways

doi: 10.1021/acscentsci.7b00589 46 YangWSKimKJGaschlerMMPatelMShchepinovMSStockwellBR

& LaSalle, J

3 However, mutations in TP53 occur in most human cancers, 4 which can abrogate the anticancer activity of TP53 and confer cancerogenic properties to mutant p53 proteins