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In 2023 a comprehensive research review completed at a medical university in Italy determined 4 : There is evidence of enhanced glutathione levels in elderly subjects with excellent physical and mental health status, suggesting that heightened glutathione may be a marker and even a causative factor of increased healthspan and lifespan

However, cytosolic H 2 O 2 generated by APx1 deficiency can trigger the adaptation to oxidative stress [27]