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Alternatively, selective exposure of reactive cysteines, especially those located within protein functional pockets or solvent-accessible regions, may confer differential susceptibility to oxidation (5860)

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Given this, the only official ASCO recommendation is that clinicians should carefully assess the risks and benefits of chemotherapy drugs known to cause CIPN, particularly in patients with pre-existing neuropathy or conditions that increase neuropathy risk, such as diabetes or a family history of neuropathy