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During the S phase, ROS activate the ATR/Chk1 signaling pathway 90 , inhibit CDC25A 91 and PCNA activity 92 , and block progression to the G2 phase through the involvement of ATM 93 and MTH1 92

Under oxidative stress, ROS can modify immune-related proteins, affecting their signaling and response to infections

* Correspondence: Kosuke Shiraishi, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers