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Ganetespib acts as a radiosensitizer in pancreatic ductal adenocarcinoma by disrupting HIF-1, STAT3, and AKT signaling and inducing G2-M cell cycle arrest, thereby impairing DNA damage repair during irradiation

An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials

In the urea cycle, it acts as an intermediate in the breakdown of ammonia, which is converted into the less toxic urea

Protein kinase R-like endoplasmic reticulum kinase (PERK) activation triggers eukaryotic initiation factor 2 alpha (eIF2) phosphorylation specifically at serine 51, leading to selective mRNA translation despite global protein synthesis attenuation