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Description

Network integration and protein structural binding analysis of neurodegeneration-related interactome

Tejedor MT, Garcia-Sobreviela MP, Ledesma M, Arbones-Mainar JM

To understand the catalytic mechanism of the ADP-ribosylhydrolase (ARH) activity of MavL, we screened its active truncation mutants and succeeded in solving the structure of the MavL 40-404 -ADPR complex at a resolution of 2.38 , which revealed that several pairs of hydrogen bonds and a - stacking interaction provided by surrounding amino acids or water molecules are involved in interactions between MavL and ADPR (Supplementary Fig