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Additionally, a study using ApoE-deficient mouse model confirmed that voluntary wheel running accelerated perfusion recovery after femoral artery ligation and increased macrophage accumulation around collateral vessels, indicating that exercise may promote collateral remodeling through inflammatory modulation ( 3 Discussion and conclusion Currently, statins are the primary pharmacological treatment for atherosclerosis, but it is worth noting that they are also commonly associated with statin-associated muscle symptoms (SAMS) (Rosenson, 2023)