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Cardiac Overexpression of Perilipin 2 Induces Atrial Steatosis, Connexin 43 Remodeling, and Atrial Fibrillation in Aged Mice

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The sources of oxidative stress in RPE cells range from high oxygen tension attributed to its close proximity to the outer retinal blood supply, the choriocapillaris, to the accumulation of autofluorescent lipid-protein aggregates that occur with aging, called lipofuscin (Sparrow and Yamamoto, 2012)