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Physicians who prescribe it do so entirely off-label, accepting medicolegal risk and the burden of informed consent

Most published findings come from short-duration animal studies or small clinical cohorts, leaving questions about long-term effects, interactions with other compounds, and use across diverse populations largely unanswered

demonstrated that the supernatant of EcN protected the TJ barrier function in sepsis both in vivo and in vitro by inhibiting the increased NF-B-mediated activation of the MLCK-P-MLC signaling pathway

It is derived from a protective protein found naturally in human gastric juice, which contributes to gut mucosal integrity and tissue repair