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The antiangiogenic therapy using the anti-VEGFA mAb bevacizumab did not lead to consistent improvements of OS and PFS, but increased its tolerability together with irinotecan (plus or not with temozolomide) (266)

In addition, UroA was effective in both lines, which suggests that UroA in monotherapy or in combination could be a good therapeutic option in bortezomib-resistant patients

Each treatment can be custom to your specific situation extra anti-nausea medication if you can't keep anything down, additional anti-inflammatory support if your head is pounding, or improved detoxification components if you really overdid it

Lancet 375(9712):385395