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One of the significant mechanisms by which CKD influences brain health is through gut-derived signals, including uremic toxins and microbial metabolites

[Abstract]2020 Sep 11;10(24):11159-11177

For instance, overexpression studies have found that ME1 promotes cancer growth and metastasis via NADPH homeostasis in various cancers including gastric cancer, basal-like breast cancer and lung cancer, etc