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Consequently, the most clinically actionable direction for mtDNA mutations lies in their detection in body fluids, especially as circulating cell-free mitochondrial DNA (cf-mtDNA) [487, 488]

Eighty-one male Sprague Dawley rats were acquired and randomly allocated into nine equal groups: healthy control group, negative control groups (receiving normal saline and carboxymethyl cellulose gel base), positive control groups (receiving asacol rectally and mesalazine orally), and test groups treated with different amounts of HAEA

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Unlike dialkyl ethers, dialkyl sulfides react rapidly with primary alkyl halides by an SN2 mechanism to give sulfonium ions (R3S+)