does oxidation state of glutathione depends on cysteine residue Structural and functional fine mapping cysteines in mammalian glutaredoxin reveal their differential susceptibility Cysteine-Mediated Redox Signaling: Chemistry, Biology,

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& Chirumbolo, S

Cyss uptake by SLC7A11/xCT induces NRF2 expression and activation Since TNBC cells are known to express high levels of the cystine/glutamate antiporter SLC7A11/xCT, we wondered whether the cellular Cyss uptake and consequently cytoplasmic Cys levels are responsible for the activation of the NRF2 pathway

One advantage that the generation of pluripotent stem cells from somatic cells brings is the possibility to cultivate patient-derived cells and to study the consequences of the disease they may carry in different cell types in a patient-specific manner