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Description

TC2N has been demonstrated to activate the Wnt signalling pathway, thus promoting the invasive metastasis of HCC cells

ATF4 transcription plays a key role in maintaining cellular homeostasis, thereby promoting cellular adaptation

GSTs are divided into 14 classes: phi (GSTF), tau (GSTU), theta (GSTT), zeta (GSTZ), lambda (GSTL), metaxin, hemerythrin (GSTH), iota (GSTI), glutathione-dependent dehydroascorbate reductase (DHAR), tetrachloro hydroquinone dehalogenase (TCHQD), -subunit classes of the eukaryotic translation elongation factor 1B (EF1B), glutathionyl hydroquinone reductase (GHR), GSTs with two thioredoxins (GST2N), and microsomal prostaglandin E synthase type 2 (mPGES2) 2,3

Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer persister cells 2,3,4