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Bernard Gressier S Lebegue Pierre Gosset B Wallaert In smoking subjects with obvious emphysema, the interaction between neutrophilderived MPO and H2O2 produced by alveolar inflammatory cells (alveolar macrophages (AM) and polymorphonuclear neutrophils (PMN)) has the ability to spontaneously inactivate, in vitro, the 1 proteinase inhibitor (1PI)

On the therapeutic front, alongside novel drug delivery strategies like levodopa inhalation powder and continuous subcutaneous infusions [8], disease-modifying therapies targeting specific molecules such as -syn and c-Abl, as well as cutting-edge approaches like immunotherapy, stem cell therapy, and gene therapy, have shown considerable potential