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According to Shuja et al 11 in his study, plasma GSH levels in melasma patients decreased significantly compared to controls and are thought to be a risk factor in the severity of melasma

C., Tseng, W

That is, while controlled low radical doses can induce adaptive and protective responses beneficial for human health, high levels of oxygen radicals may drive base oxidation, DNA strand breaks, and lipid peroxidation for amplified inflammation and cell death [252]