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Orlando (FL) Martin SL, Downey D, Bilton D, et al

down-regulated ROS, prostaglandin-peroxide synthase (PTGS2), and COX2

Eventually, the main determinant of brain delivery efficacy is the concentration of the active (parent) drug at site of action in the brain or an increase of the relative distribution of parent drug between the brain and other tissues after administration of prodrug or nanocarriers compared to parent drug dosing

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