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Karanth School of Health Professions and Human Services, Hofstra University, Hempstead, NY, USA Ibraheem M

Generally, lipid peroxidation can be divided into two types: enzymatic oxidation (with enzymes) and free radical chain reactions (non-enzymatic), through which PUFA can be oxidized and broken down into toxic derivatives such as 4-HNEs and malondialdehyde (MDA) (Feng and Stockwell, 2018)

To overcome this constraint, CNS-directed strategies often employ receptor-mediated transcytosis through engineered formats such as bispecific antibodies or brain-shuttle constructs targeting BBB receptors (e.g., TfR or insulin receptor) together with pathological targets such as A or tau, thereby improving brain delivery compared with conventional antibodies (Terstappen et al., 2021)

Category 3: Incorrect Potential Match in EI-MS Corrected by CID An example of low EI-MS score which was incorrectly identified compounds in the NIST database search is coniferyl aldehyde (Figure 5) which was originally identified as 4-methoxy cinnamic acid with EI-MS score of 690