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Abstract High-throughput phenotype-based screening of large libraries of novel compounds without known targets can identify small molecules that elicit a desired cellular response, but additional approaches are required to find and characterize their targets and mechanisms of action

Intradiscal electrothermal therapy (IDET), a form of annuloplasty, is a minimally invasive surgical procedure where heat is applied to the AF through a catheter, preventing future ruptures through the change in collagen structure and burning of nociceptors to decrease the level of pain (Saal and Saal, 2000a

An allergic reaction to NAC or any component of the preparation 6

Some natural ingredients were reported to target tyrosinase expression through MITF pathway, like resveratrol or -viniferin, a resveratrol oligomer that improved facial melasma and freckles [102]