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Levels of angiogenic cytokines prior to disease progression in metastatic colorectal cancer patients treated with bevacizumab

Clinical studies have shown that reduced glutathione concentration and/or a disproportionate ratio of GSH:GSSG [glutathione to oxidized glutathione] has been associated with a number of diseases, including cancer, human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS), hepatitis, type 2 diabetes, Parkinsons disease, and cystic fibrosis (Allen & Bradley, 2011)

In order to be able to penetrate through the skins layers, particularly the SC, the optimal log P value of a chemical entity should be within the range of 13 [229,230]