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Thus, cellular metabolic pathways and immunological responses (such as the production of important transcription factors) are closely regulated in both directions, either preserving immune homeostasis or aiding in the pathophysiology of illness

Lupus is an autoimmune disease, meaning the bodys defense system changes and then attacks and destroys normal tissue, causing inflammation and organ damage (x)

446 Studies suggest that for patients who respond poorly to mesalazine, sulfasalazine may provide an alternative that reduces inflammation and ulceration of the intestinal mucosa and possibly improves the local immune response

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